Ca2+ Dysregulation Induces Mitochondrial Depolarization and Apoptosis
نویسندگان
چکیده
منابع مشابه
Anti-CD44 induces apoptosis in T lymphoma via mitochondrial depolarization
A blockade of CD44 can interfere with haematopoietic and leukemic stem cell homing, the latter being considered as a therapeutic option in haematological malignancies. We here aimed to explore the molecular mechanism underlying the therapeutic efficacy of anti-CD44. We noted that in irradiated mice reconstituted with a bone marrow cell transplant, anti-CD44 exerts a stronger effect on haematopo...
متن کامل4-Hydroxynonenal Induces Endothelial Apoptosis through Mitochondrial Depolarization
Young Mi Kwon, Jaewon Lee, Hyung Suk Baik, Byung Pal Yu and Hae Young Chung* College of Pharmacy, Pusan National University, Busan 609-735, Korea MRC for Ischemic Tissue Regeneration, College of Medicine, Pusan National University, Busan 602-739, Korea 3 Genetic Engineering Research Institute, Pusan National University, Busan, 609-735, Korea Department of Physiology, The University of Texas Hea...
متن کاملEconazole Nitrate Induces Apoptosis in MCF-7 Cells via Mitochondrial and Caspase Pathways
Econazole nitrate (EN), a synthetic compound, is now in use as a routine antifungal drug. EN was shown to have antitumor effect, the tumor cell killing mechanisms, however, remain unclear. In this research, the apoptosis-inducing effect of EN on MCF-7 cells was investigated. The results showed that EN inhibited the proliferation of MCF-7 cells in a time- and dose-dependent manner by MTT method ...
متن کاملEconazole Nitrate Induces Apoptosis in MCF-7 Cells via Mitochondrial and Caspase Pathways
Econazole nitrate (EN), a synthetic compound, is now in use as a routine antifungal drug. EN was shown to have antitumor effect, the tumor cell killing mechanisms, however, remain unclear. In this research, the apoptosis-inducing effect of EN on MCF-7 cells was investigated. The results showed that EN inhibited the proliferation of MCF-7 cells in a time- and dose-dependent manner by MTT method ...
متن کاملEpigallocatechin-3-gallate induces mitochondrial membrane depolarization and caspase-dependent apoptosis in pancreatic cancer cells.
Polyphenols such as epigallocatechin-3-gallate (EGCG) from green tea extract can exert a growth-suppressive effect on human pancreatic cancer cells in vitro. In pursuit of our investigations to dissect the molecular mechanism of EGCG action on pancreatic cancer, we observed that the antiproliferative action of EGCG on pancreatic carcinoma is mediated through programmed cell death or apoptosis a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2005
ISSN: 0021-9258
DOI: 10.1074/jbc.m505223200